BTNL2 gene SNPs as a contributing factor to sarcoidosis pathogenesis in a cohort of Greek patients
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چکیده
منابع مشابه
BTNL2 gene SNPs as a contributing factor to sarcoidosis pathogenesis in a cohort of Greek patients
Sarcoidosis is a multisystemic granulomatous disease of unknown etiology that primarily affects adults between the ages of 20 and 40 years old. It is characterized by the activation of Th1 lymphocytes resulting in the production of inflammatory cytokines and the formation of noncaseating epithelioid cell granulomas in affected tissues. The lungs and lymphatic system are the ones most frequently...
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Background: In 10-30% of the cases with sarcoidosis, skin lesions appear solely without any systemic signs or symptoms. BTNL2 gene, which is a member of the immunoglobulin gene super family and is associated with CD86 and CD80 co-stimulatory receptors, is identified to play an important role in the establishment of sarcoidosis. We aimed to evaluate the role of this gene in patients with skin sa...
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متن کاملBTNL2 Gene Polymorphism and Sarcoidosis Susceptibility: A Meta-Analysis
BACKGROUND Butyrophilin-like 2 (BTNL2) rs2076530 gene polymorphism has been implicated in susceptibility to sarcoidosis. However, results from previous studies are not consistent. To assess the association of BTNL2 polymorphism and sarcoidosis susceptibility, a meta-analysis was performed. METHODS PubMed, Embase were searched for eligible case-control studies. Data were extracted and pooled o...
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ژورنال
عنوان ژورنال: Meta Gene
سال: 2014
ISSN: 2214-5400
DOI: 10.1016/j.mgene.2014.07.009